The research enterprise in the CMB Program is well-funded by extramural support in the form of individual research awards, program projects grants, and pre- and post-doctoral training grants. Funding sources include the National Institutes of Health, National Science Foundation, American Heart Association, USDA, DOD and NASA. Large interdisciplinary, multi-investigator grants fund research projects in cancer biology, cardiovascular biology and cell motility, environmental pathology, immunobiology, neuroscience, and pulmonary function and disease.
In addition, students have access to cutting-edge equipment and focused training in our core facilities. These facilities include the Bioinformatics, X-Ray Crystallography, DNA Analysis, Flow Cytometry, and Microscopy and Imaging.
Note: Faculty listed below have self identified their participation in these areas, and may be listed in multiple categories. For an alphabetical list of faculty, please visit the faculty directory.
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Cancer Biology and Genome Stability| Name | Areas of Expertise and/or Research |
|---|
| Cellular events which mediate thyroid hormone action in development and pathophysiology |
| Cancer Biology, Neurodegenerative disorders, DNA repair, translesion synthesis, stress responses |
| Mitochondrial biology, cancer metabolism, cell migration and redox biology |
| Paula Deming | Molecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology |
| Sylvie Doublie | Molecular Mechanisms of DNA Repair |
| Christopher Francklyn | Protein Synthesis in Biological Regulation and Human Disease |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Karen Glass | Structure and function of epigenetic reader domains |
| Jessica Heath | Pediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development |
| Robert Hondal | Mechanism of Thioredoxin Reductase — a Collaborative Project |
| Alan Howe | Regulation of cell migration by extracellular matrix |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Christopher Landry | Materials Chemistry, Nanotechnology, and Particles in Biology |
| DNA Repair |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| Extracellular matrix dysfunction in uterine leiomyoma and leiomyosarcoma |
| David Pederson | DNA Replication and Repair in Chromatin |
| Delphine Quenet | PARP Biology and Chromatin |
| Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| Functional Genomics, Cancer Metabolism, Epigenetics |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Lactation physiology, mammary gland biology, breast cancer, and endocrine regulation |
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Genomics and Computational Biology| Name | Areas of Expertise and/or Research |
|---|
| Sylvie Doublie | Molecular Mechanisms of DNA Repair |
| Food safety, food microbiology, bacterial stress tolerance, bacterial genetics |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Karen Glass | Structure and function of epigenetic reader domains |
| Jonathan Gordon | Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions |
| Jane Lian | Bone biology and pathogenesis |
| RNA Biology, Immunology, Single Molecule Biophysics |
| Shanmugasundaram Nallasamy | Small non-coding RNAs regulating myometrial extracellular matrix |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
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Immunology and Microbial Pathogenesis| Name | Areas of Expertise and/or Research |
|---|
| Eyal Amiel | Metabolic Regulation of Dendritic Cell Activation and Immune Function |
| John Barlow | Mathematical and molecular epidemiology of infectious disease; Host-Pathogen interactions in mastitis; Cattle MHC |
| Elizabeth Bonney | Maternal immunity and tolerance |
| Jason Botten | Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines |
| Jonathan Boyson | The regulation and function of innate-like T cells |
| Cell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza) |
| Ralph Budd | Death receptor regulation of apoptosis in the immune system |
| Jean Celli | Cellular and molecular mechanisms of proliferation of intracellular bacterial pathogens; Brucella pathogenesis;Type IV secretion; intracellular organelle biology |
| Sean Diehl | Vaccines and immunology |
| Food safety, food microbiology, bacterial stress tolerance, bacterial genetics |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Christopher Huston | Host-Pathogen Interactions of Intestinal Protozoa |
| Leigh Knolder | Bacteria-host interactions; Enteric bacteria |
| Dimitry Krementsov | Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome |
| Enteric viral infections and immunology, vaccines |
| RNA Biology, Immunology, Single Molecule Biophysics |
| Parasitology & Microbiology |
| Matthew Poynter | Airway epithelium in innate and adaptive immune responses |
| Markus Thali | Multiscale analyses of HIV-1 cell-to-cell transmission |
| Gary Ward | Cell Biology of Host-Parasite Interaction |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
| Daniel Weiss | Gene and stem cell therapies for lung diseases |
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Lung and Cardiovascular Biology| Name | Areas of Expertise and/or Research |
|---|
| Vikas Anathy | Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases |
| Frances Carr | Cellular events which mediate thyroid hormone action in development and pathophysiology |
| Mitochondrial biology, cancer metabolism, cell migration and redox biology |
| Benedek Erdos | Neural control of cardiovascular function; stress, obesity and aging |
| Stephen Everse | Structure & Function of Proteins |
| Kalev Freeman | Trauma physiology/ traumatic brain injury |
| Yvonne Janssen-Heininger | Transcriptional regulators of lung responses to injury and inflammation |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| Ion channels and calcium signaling in smooth muscle and endothelial cells |
| Matthew Poynter | Airway epithelium in innate and adaptive immune responses |
| Arti Shukla | Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies |
| Jay Silveira | Biochemistry of Platelet Function |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| Doug Taatjes | Cell imaging and disease |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Kathleen Trybus | Molecular motors and their tracks |
| Albert van der Vliet | Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
| David Warshaw | Myosin Molecular Motors |
| Daniel Weiss | Gene and stem cell therapies for lung diseases |
| George Wellman | Cerebral artery function in health and disease |
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Molecular Cell Biology and Genetics| Name | Areas of Expertise and/or Research |
|---|
| Vikas Anathy | Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases |
| Jason Botten | Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines |
| Signal Transduction, Proteomics, Neuroscience |
| Cell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza) |
| Ralph Budd | Death receptor regulation of apoptosis in the immune system |
| Benedek Erdos | Neural control of cardiovascular function; stress, obesity and aging |
| Alan Howe | Regulation of cell migration by extracellular matrix |
| Yvonne Janssen-Heininger | Transcriptional regulators of lung responses to injury and inflammation |
| Thomas Jetton | Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Dimitry Krementsov | Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| RNA Biology, Immunology, Single Molecule Biophysics |
| Anthony Morielli | Molecular mechanisms of ion channel regulation in the brain |
| Shanmugasundaram Nallasamy | Structure and function of extracellular matrix in term and preterm birth |
| Michael Previs | Molecular mechanisms of muscle |
| Delphine Quenet | PARP biology and chromatin |
| John Salogiannis | Molecular mechanisms and live cell imaging of intracellular organelle movement in health and disease" |
| Functional Genomics, Cancer Metabolism, Epigenetics |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Doug Taatjes | Cell imaging and disease |
| Markus Thali | Multiscale analyses of HIV-1 cell-to-cell transmission |
| Mary Tierney | Mechanisms for controlling cell function through ECM structure |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Albert van der Vliet | Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling |
| Jim Vigoreaux | Biology of insect flight muscle and vertebrate cardiac muscle |
| Gary Ward | Cell Biology of Host-Parasite Interaction |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
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Stem Cell And Developmental Biology| Name | Areas of Expertise and/or Research |
|---|
| Signal Transduction, Proteomics, Neuroscience |
| Elizabeth Bonney | Maternal immunity and tolerance |
| Jonathan Gordon | Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions |
| Thomas Jetton | Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Mary Tierney | Mechanisms for controlling cell function through ECM structure |
| Daniel Weiss | Gene and stem cell therapies for lung diseases. |
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Structural Biology and Biophysics| Name | Areas of Expertise and/or Research |
|---|
| Christopher Berger | Molecular Mechanisms of Axonal Transport |
| Sylvie Doublie | X-Ray Crystallography |
| Stephen Everse | Structure & Function of Proteins |
| Christopher Francklyn | Structure and Function of Nucleic Acid Binding Proteins |
| Karen Glass | Structure and function of epigenetic reader domains |
| Robert Hondal | Mechanism of Thioredoxin Reductase — a Collaborative Project |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| DNA Repair |
| y | Mechanical function of the myometrium during pregnancy and parturition |
| Ion channels and calcium signaling in smooth muscle and endothelial cells |
| David Pederson | DNA Replication and Repair in Chromatin |
| Molecular mechanisms of muscle |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Jason Stumpff | Molecular Control of Cell Division |
| Kathleen Trybus | Molecular motors and their tracks |
| David Warshaw | Myosin Molecular Motors |
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